Safety and immunogenicity of GamEvac-Combi, a heterologous rVSV- and rAd5-vectored Ebola vaccine: a randomized controlled multicenter clinical trial in the Republic of Guinea and Russia

Safety and immunogenicity of GamEvac-Combi, a heterologous rVSV- and rAd5-vectored Ebola vaccine: a randomized controlled multicenter clinical trial in the Republic of Guinea and Russia

BackgroundEbola virus disease (EVD) is one of the most dangerous and lethal diseases affecting humans. There are several licensed vaccines against EVD, but it remains one of the priority diseases for research and development of effective vaccines.MethodsA double-blind randomized placebo-controlled t...

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Main Authors: Denis Y. Logunov, Inna V. Dolzhikova, Mamadou Y. Boiro, Anna V. Kovyrshina, Alina S. Dzharullaeva, Alina S. Erokhova, Daria M. Grousova, Amir I. Tukhvatulin, Fatima M. Izhaeva, Yana V. Simakova, Maria K. Ordzhonikidze, Nadezhda L. Lubenets, Olga V. Zubkova, Dmitrii V. Scheblyakov, Ilias B. Esmagambetov, Maksim M. Shmarov, Alexander S. Semikhin, Natalia M. Tukhvatulina, Dmitrii N. Shcherbinin, Irina L. Tutykhina, Georgiy S. Prokhorov, Alexander A. Khovaev, Tatiana N. Demidova, Nikolai A. Malishev, Liliya N. Merkulova, Olga L. Voronina, Irina T. Fedyakina, Lidiya B. Kisteneva, Lyudmila V. Kolobukhina, Dmitry V. Mishin, Aleksandr L. Elakov, Ekaterina I. Ermolova, Kirill G. Krasnoslobodtsev, Viktor F. Larichev, Irina S. Kruzhkova, Egor M. Burmistrov, Anna B. Sheremet, Elizaveta A. Tokarskaya, Alexander V. Gromov, Dmitrii A. Reshetnikov, Aleksandr I. Fisun, Bogdan N. Kotiv, Dmitrii V. Ovchinnikov, Evgenii V. Ivchenko, Konstantin V. Zhdanov, Sergei M. Zakharenko, Aleksandr N. Solovev, Andrei M. Ivanov, Vitalii S. Sukachev, Roman V. Gudkov, Oleg V. Maltsev, Ilnur A. Gabdrakhmanov, Anton V. Barsukov, Vladislav V. Vashchenkov, Nikolai I. Demianenko, Sergei B. Ignatev, Konstantin V. Asiamov, Nikolai N. Kirichenko, Andrei V. Liubimov, Igor I. Volkov, Evgenii V. Kriukov, Nikolai K. Bazarnov, Viktoriia A. Kolodiazhnaia, Elena V. Kolomoets, Svetlana I. Syromyatnikova, Dmitry E. Chifanov, Alexander F. Andrus, Dmitry A. Kutaev, Sergei V. Borisevich, Boris S. Naroditsky, Alexander L. Gintsburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
clinical trials
vector vaccine
EVD
Ebola vaccine
prime-boost
rVSV
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487039/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487039/full

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