MEGDTA: multi-modal drug-target affinity prediction based on protein three-dimensional structure and ensemble graph neural network

Abstract Background Drug development is a time-consuming and costly endeavor, and utilizing computer-aided methods to predict drug-target affinity (DTA) can significantly accelerate this process. The key to accurate DTA prediction lies in selecting appropriate computational models to effectively ext...

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Bibliographic Details
Main Authors: Zhanwei Hou, Yijun Li, Haixia Zhai, Junwei Luo, Yulian Ding, Yi Pan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:BMC Genomics
Subjects:
Online Access:https://doi.org/10.1186/s12864-025-11943-w
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