Dexmedetomidine potently and reversibly regulates stress-mediated behaviors

AimsDemonstrate that dexmedetomidine is potentially useful for treatment of psychiatric symptoms caused by acute or chronic stress by using relevant rodent models and doses predicted to achieve sufficient brain levels to activate alpha2-adrenoceptors.MethodsIn vitro characterization was performed us...

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Bibliographic Details
Main Authors: Frank D. Yocca, Dinesh K. Dhull, Subhendu Seth, Manisha Chugh, Sameer Sharma, Krishnan Nandabalan, Friso R. Postma, Michael De Vivo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1589075/full
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