Serum IL-1β, IL-2, and IL-6 in Insulin-Dependent Diabetic Children
Insulin-dependent diabetes mellitus (IDDM) is a chronic disease characterized by T-cell-dependent autoimmune destruction of the insulin-producing β cells in the pancreatic islets of Langerhans, resulting in an absolute lack of insulin. T cells are activated in response to islet-dominant autoantigens...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2006-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/MI/2006/59206 |
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| Summary: | Insulin-dependent diabetes mellitus (IDDM) is a chronic disease
characterized by T-cell-dependent autoimmune destruction of the
insulin-producing β cells in the pancreatic islets of
Langerhans, resulting in an absolute lack of insulin. T cells are
activated in response to islet-dominant autoantigens, the result
being the development of IDDM. Insulin is one of the islet
autoantigens responsible for the activation of T-lymphocyte
functions, inflammatory cytokine production, and development of
IDDM. The aim of this study was to investigate serum
concentrations of interleukin (IL)-1β, IL-2, IL-6, and tumor necrosis factor (TNF)-α in children IDDM. The study
population consisted of 27 children with IDDM and 25 healthy
controls. Children with IDDM were divided into three subgroups:
(1) previously diagnosed patients (long standing IDDM)
(n:15), (2) newly diagnosed patients with diabetic ketoacidosis
(before treatment)
(n:12), and (3) newly diagnosed patients
with diabetic ketoacidosis (after treatment for two weeks)
(n:12). In all stages of diabetes higher levels of IL-1β and TNF-α and lower levels of IL-2 and IL-6 were detected. Our
data about elevated serum IL-1β, TNF-α and decreased IL-2, IL-6 levels in newly diagnosed IDDM patients in
comparison with longer standing cases supports an activation of
systemic inflammatory process during early phases of IDDM which
may be indicative of an ongoing β-cell destruction. Persistence of significant difference between the cases with IDDM
monitored for a long time and controls in terms of IL-1β, IL-2, IL-6, and TNF-α supports continuous activation during the late stages of diabetes. |
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| ISSN: | 0962-9351 1466-1861 |