PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

PLK1 blockade enhances the anti-tumor effect of MAPK inhibition in pancreatic ductal adenocarcinoma

Summary: Despite constitutive Ras/Raf/MAPK pathway activation in most pancreatic ductal adenocarcinomas (PDACs), treatment approaches targeting this pathway have primarily been unsuccessful. We conduct a drug library screen on an MEK inhibitor (MEKi)-resistant PDAC model and perform complementary pa...

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Main Authors: Ben Zhao, Rui Fang, Hendrik Schürmann, Erik Jan Hemmer, Gina Lauren Mayer, Marija Trajkovic-Arsic, Kristina Althoff, Jiajin Yang, Laura Godfrey, Sven T. Liffers, Konstantinos Savvatakis, Madeleine Dorsch, Barbara M. Grüner, Stephan Hahn, Marc Remke, Smiths S. Lueong, Jens T. Siveke
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725003122
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http://www.sciencedirect.com/science/article/pii/S2211124725003122

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