Microbiota-associated immunotherapy resistance caused by deficient PD-L2 - RGMb signaling
In a recent paper in Nature, Park et al. propose a mechanism through which intestinal dysbiosis compromises the efficacy of immunotherapy targeting the PD-L1/PD−1 interaction. Dysbiosis may upregulate a pair of checkpoint molecules, i.e. PD-L2 interacting with RGMb. Antibodies targeting PD-L2/RGMb c...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | OncoImmunology |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2023.2224679 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|