MARCO expression on myeloid-derived suppressor cells is essential for their differentiation and immunosuppression

Abstract Myeloid-derived suppressor cells (MDSCs) significantly contribute to the immunosuppressive tumor microenvironment (TME), and targeted inhibition of MDSCs is a potential therapeutic strategy against cancer. Here, we identify macrophage receptor with collagenous structure (MARCO) as a critica...

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Bibliographic Details
Main Authors: Sijia Liu, Binle Tian, Na Wang, Zhilong Wang, Wen Zhang, Qi Li, JianFei Wang, Guo-Huang Fan, Caicun Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-025-02627-1
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