CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation

CRISPR-based screening identifies the role of KRAB-containing transcription factors ZIM3 and ZNF394 in human major zygotic genome activation

Summary: The initiation of major zygotic genome activation (ZGA) is crucial for human early embryogenesis. However, the transcription factors (TFs) regulating major ZGA in humans remain largely unknown. Here, we performed a CRISPR-based activation screen of 1,603 human TFs in human extended pluripot...

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Bibliographic Details
Main Authors: Jiayu Li, Liangfu Xie, Cheng Shi, Tiantian Zhang, Xiwen Lin, Haokun Da, Kongqianqian Sun, Chunsheng Han, Bing Zhu, Xi Chen, Hongkui Deng, Jun Xu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007867
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