Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy

Inhibiting ADORA1 enhances glioma apoptosis and increases its sensitivity to anti-PD1 therapy

IntroductionGlioma, the primary cancerous tumor of the central nervous system in adults, has a poor outlook. Immune checkpoint blockade therapy has exhibited notable efficacy against various cancer types. Prior research has suggested that the adenosine A1 receptor (ADORA1) facilitates the proliferat...

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Bibliographic Details
Main Authors: Hong-jiang Li, Zhi-yun Yu, Hua-ping Gao, Yi-ran Xu, Xue-yuan Li, Wei Jiang, Di Chen, Dong-ming Yan, Chao Yang, Xian-zhi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
glioma
ADORA1
apoptosis
PD1
kininogen-1
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1545780/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1545780/full

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