Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study

Comparison of commercial and in-house tissue-based and cell-based assays for the detection of autoantibodies targeting neuronal surface proteins: a prospective cohort study

IntroductionThe detection of antibodies targeting neuronal antigens is a keystone for the diagnosis of autoimmune encephalitis (AE) and paraneoplastic neurological syndromes (PNS). This study aimed to compare the performance of a commercial tissue-based immunofluorescence assay (cIFA) to that of an...

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Main Authors: David Goncalves, Marie Benaiteau, Véronique Rogemond, Sterenn Closs, Anne-Laurie Pinto, Maroua Dhairi, Marine Villard, Géraldine Picard, Nicole Fabien, Jérôme Honnorat
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
autoimmune encephalitis
paraneoplastic neurological syndromes
autoantibodies
diagnostic test
immunofluorescence assays
tissue-based assay
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563877/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1563877/full

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