A novel combined quadrivalent self-amplifying mRNA-LNP vaccine provokes protective immunity against acute and chronic toxoplasmosis in mice

A novel combined quadrivalent self-amplifying mRNA-LNP vaccine provokes protective immunity against acute and chronic toxoplasmosis in mice

Abstract Background Toxoplasma gondii, an intracellular parasitic protozoan, which infects almost all warm-blooded animals, including humans, causes toxoplasmosis. However, we lack effective drugs and vaccines to control toxoplasmosis, representing a clinical challenge. Therefore, safe and effective...

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Main Authors: Qinli Wu, Zhongao Zhang, Hongkun Chu, Bing Xia, Weiqi Li, Jianzu Ding, Haojie Ding, Bin Zheng, Meng Gao, Youru Wang, Eman E. El Shanawany, Feng Tan, Huayue Ye, Xunhui Zhuo, Shaohong Lu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Infectious Diseases of Poverty
Subjects:
Toxoplasma gondii
mRNA vaccine
Self-amplifying
Immune protection
Oocyst
Online Access:https://doi.org/10.1186/s40249-025-01332-6
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https://doi.org/10.1186/s40249-025-01332-6

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