Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?

Pharmacokinetics and Metabolism of Broad-Spectrum Antivirals Remdesivir and Obeldesivir with a Consideration to Metabolite GS-441524: Same, Similar, or Different?

RNA viruses with pandemic potential pose a significant global health risk. The adenosine nucleoside analog GS-441524 is metabolized to its active GS-443902 triphosphate metabolite to inhibit a broad spectrum of RNA viruses. Intravenous (IV) remdesivir (RDV) and oral obeldesivir (ODV) are phosphorami...

Full description

Saved in:
Bibliographic Details
Main Authors: Darius Babusis, Cynthia Kim, Jesse Yang, Xiaofeng Zhao, Guoju Geng, Carmen Ip, Nathan Kozon, Hoa Le, Jennifer Leung, Jared Pitts, Dustin S. Siegel, Rao Kalla, Bernard Murray, John P. Bilello, Roy Bannister, Richard L. Mackman, Raju Subramanian
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
pharmacokinetics
remdesivir
obeldesivir
antivirals
GS-441524
GS-443902
Online Access:https://www.mdpi.com/1999-4915/17/6/836
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1999-4915/17/6/836

Similar Items