Optimized chemical labeling method for isolation of 8-oxoG-modified RNA, ChLoRox-Seq, identifies mRNAs enriched in oxidation and transcriptome-wide distribution biases of oxidation events post environmental stress

Optimized chemical labeling method for isolation of 8-oxoG-modified RNA, ChLoRox-Seq, identifies mRNAs enriched in oxidation and transcriptome-wide distribution biases of oxidation events post environmental stress

Bulk increases in nucleobase oxidation, most commonly manifesting as the guanine (G) nucleobase modification 8-oxo-7,8-dihydroguanine (8-oxoG), have been linked to several disease pathologies. Elucidating the effects of RNA oxidation on cellular homoeostasis is limited by a lack of effective tools f...

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Bibliographic Details
Main Authors: Matthew R. Burroughs, Philip J. Sweet, Lydia M. Contreras
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:RNA Biology
Subjects:
8-oxoG
RNA modifications
epitranscriptome
air pollution
oxidative stress
next generation sequencing
Online Access:https://www.tandfonline.com/doi/10.1080/15476286.2024.2427903
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https://www.tandfonline.com/doi/10.1080/15476286.2024.2427903

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