HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.

HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.

Certain Major Histocompatibility-I (MHC-I) types are associated with superior immune containment of HIV-1 infection by CD8+ cytotoxic T lymphocytes (CTLs), but the mechanisms mediating this containment are difficult to elucidate in vivo. Here we provide controlled assessments of fitness landscapes a...

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Bibliographic Details
Main Authors: Aleksandr M Gorin, Yushen Du, Franklin Y Liu, Tian-Hao Zhang, Hwee L Ng, Christian Hofmann, William G Cumberland, Ren Sun, Otto O Yang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006541&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1006541&type=printable

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