CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation

CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation

Abstract Background Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex differences. CTCF, a master chromatin conformation regulator, is enriche...

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Main Authors: He Fang, Ana R. Tronco, Giancarlo Bonora, Truong Nguyen, Jitendra Thakur, Joel B. Berletch, Galina N. Filippova, Steven Henikoff, Jay Shendure, William S. Noble, Zhijun Duan, Christine M. Disteche, Xinxian Deng
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Biology
Subjects:
CTCF
Chromatin looping
Insulation
X-chromosome inactivation
Escape from X-chromosome inactivation
Online Access:https://doi.org/10.1186/s12915-025-02137-7
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https://doi.org/10.1186/s12915-025-02137-7

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