ICU patient-on-a-chip emulating orchestration of mast cells and cerebral organoids in neuroinflammation

Abstract Propofol and midazolam are the current standard of care for prolonged sedation in Intensive Care Units (ICUs). However, the effects and mechanism of these sedatives in brain tissue are unclear. Herein, the development of an ICU patient-on-a-chip platform to elucidate those effects is report...

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Main Authors: Pelin Saglam-Metiner, Sena Yanasik, Yusuf Caglar Odabasi, Jennifer Modamio, Moritz Negwer, Cigir Biray-Avci, Ayse Guler, Ali Erturk, Ender Yildirim, Ozlem Yesil-Celiktas
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07313-z
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