Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL

Natural Polyamine Spermidine Inhibits the In Vitro Oxidation of LDL

Spermidine is a natural autophagy-inducer and anti-aging compound. Herein, we investigated a potential autophagy-independent mechanism of spermidine, namely its capability to directly impede LDL oxidation, an early step in atherogenesis. In our in vitro-model, LDL oxidation was induced by the additi...

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Bibliographic Details
Main Authors: Christine Rossmann, Azra Darko, Gerd Kager, Gerhard Ledinski, Willibald Wonisch, Thomas Wagner, Seth Hallström, Gilbert Reibnegger, Margret Paar, Gerhard Cvirn
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Molecules
Subjects:
antioxidants
atherogenesis
copper ions
endothelial damage
lipid oxidation
Online Access:https://www.mdpi.com/1420-3049/30/4/955
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