Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay

Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay

Abstract Background Artemisinin partial resistance (ART-R) has spread throughout Southeast Asia and mutations in Pfkelch13, the molecular marker of resistance, are widely reported in East Africa. Effective in vitro assays and robust phenotypes are crucial for monitoring populations for the emergence...

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Main Authors: Mackenzie A. C. Sievert, Tarrick Qahash, Puspendra P. Singh, Douglas A. Shoue, Lisa A. Checkley, Katelyn Vendrely Brenneman, Zione Cassady, Sudhir Kumar, Xue Li, François H. Nosten, Timothy J. C. Anderson, Ashley M. Vaughan, Jeanne Romero-Severson, Michael T. Ferdig
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Malaria Journal
Subjects:
Ring-stage survival assay
Artemisinin resistance
Plasmodium falciparum
Kelch13
Phenotypes
Genetic cross
Online Access:https://doi.org/10.1186/s12936-025-05481-9
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https://doi.org/10.1186/s12936-025-05481-9

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