Deciphering the complex clonal heterogeneity of polycythemia vera and the response to interferon alfa

Deciphering the complex clonal heterogeneity of polycythemia vera and the response to interferon alfa

Abstract: Interferon alfa (IFN-α) is approved for the therapy of patients with polycythemia vera (PV), a subtype of myeloproliferative neoplasm (MPN). Some patients achieve molecular responses (MRs), but clonal factors sensitizing for MRs remain elusive. We integrated colony formation assays with si...

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Main Authors: Milena Kalmer, Martin Grasshoff, Tiago Maié, Kristina Pannen, Marcelo A.S. Toledo, Margherita Vieri, Kathrin Olschok, Rebecca Lemanzyk, Jelena Lazarevic, Baerbel Junge, Julian Baumeister, Angela Galauner, Noa Chapal Ilani, Dror Bar, Elia Colin, Mingbo Cheng, Joelle Schifflers, Kim Kricheldorf, Mirle Schemionek, Tim H. Brümmendorf, Ralf Weiskirchen, Liran Shlush, Martin Zenke, Nicolas Chatain, Ivan G. Costa, Steffen Koschmieder
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925000552
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