Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors

Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors

Abstract Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the therapeutic benefit of direct STING agonists appears limited. In this study, we use several artificial intelligence techniques and patient-based multi-omics data to show that Ectonucleotide...

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Main Authors: Congying Pu, Hui Cui, Huaxing Yu, Xin Cheng, Man Zhang, Luoheng Qin, Zhilin Ning, Wen Zhang, Shan Chen, Yuhang Qian, Feng Wang, Ling Wang, Xiaoxia Lin, David Gennert, Frank W. Pun, Feng Ren, Alex Zhavoronkov
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59874-0
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https://doi.org/10.1038/s41467-025-59874-0

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