Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease

Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer’s disease

BackgroundThe 3xTg-AD transgenic mouse model of Alzheimer’s disease (AD) is an important tool to investigate the relationship between development of pathological amyloid-β (Aβ) and tau, neuroinflammation, and cognitive impairments. Traditional behavioral tasks assessing aspects of learning and memor...

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Bibliographic Details
Main Authors: Jessica M. Judd, Wendy Winslow, Ian McDonough, Faizan Mistry, Ramon Velazquez
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
IntelliCage
reaction time task
3xTg-AD mouse
Alzheimer’s disease
impulsivity
attention
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2024.1466415/full
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https://www.frontiersin.org/articles/10.3389/fnagi.2024.1466415/full

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