A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia
Abstract Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. Atherogenic index of plasma (AIP) is a novel indicator of atherosclerotic status based on triglycerides and high-density lipoprotein choleste...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-86398-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594794723934208 |
|---|---|
| author | Zhiping Duan Yunda Huang Xiaoling Liu Huiyu Tang Guihua Jiang Wei Huang Runfen Du Dan Zhou Hong Yang |
| author_facet | Zhiping Duan Yunda Huang Xiaoling Liu Huiyu Tang Guihua Jiang Wei Huang Runfen Du Dan Zhou Hong Yang |
| author_sort | Zhiping Duan |
| collection | DOAJ |
| description | Abstract Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. Atherogenic index of plasma (AIP) is a novel indicator of atherosclerotic status based on triglycerides and high-density lipoprotein cholesterol. The aim of this study was to investigate the association between AIP and new-onset sarcopenia and its components among middle-aged and older adults in a Chinese community. This cohort study included 7,992 participants who were free of sarcopenia in 2011 in the China Health and Retirement Longitudinal Study and were followed up in 2013 and 2015. Sarcopenia was assessed using the recommendations of the Asian Working Group for Sarcopenia 2019. Longitudinal associations between AIP and sarcopenia and its components were assessed using Cox proportional risk regression modeling. The results showed that AIP was negatively associated with sarcopenia [HR and 95% CI: 0.73 (0.62–0.86)]; with muscle mass [β and 95%CI: 0.49 (0.4–0.57)], skeletal muscle mass index [β and 95%CI: 0.17 (0.15–0.2)], and grip strength [β and 95% CI: 0.17 (0.15–0.2)] being positively correlated. A lower AIP was associated with a lower muscle mass and handgrip strength and higher incidence of sarcopenia. Regular measurement of AIP in the middle-aged and older population in the community can help in the early diagnosis and intervention of sarcopenia. |
| format | Article |
| id | doaj-art-cfa1231cd935496aafcd62a2c54320ef |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-cfa1231cd935496aafcd62a2c54320ef2025-01-19T12:22:26ZengNature PortfolioScientific Reports2045-23222025-01-011511910.1038/s41598-025-86398-wA lower atherogenic index of plasma was associated with a higher incidence of sarcopeniaZhiping Duan0Yunda Huang1Xiaoling Liu2Huiyu Tang3Guihua Jiang4Wei Huang5Runfen Du6Dan Zhou7Hong Yang8Department of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityDepartment of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityRadiotherapy Department, Yunnan Cancer Hospital, The Third Affiliated Hospital of Kunming Medical University, Peking University Cancer Hospital YunnanDepartment of Geriatrics and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan UniversityDepartment of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityDepartment of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityDepartment of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityMental Hospital of Yunnan Province, Mental Health Centre affiliated to Kunming Medical University, Mental Health Prevention and Control Centre of Yunnan ProvinceDepartment of Geriatrics, The Third People’s Hospital of Yunnan Province, The Second Affiliated Hospital of Dali UniversityAbstract Sarcopenia is an age-related muscle senescence disease that leads to functional limitations, physical disability and premature death in older adults. Atherogenic index of plasma (AIP) is a novel indicator of atherosclerotic status based on triglycerides and high-density lipoprotein cholesterol. The aim of this study was to investigate the association between AIP and new-onset sarcopenia and its components among middle-aged and older adults in a Chinese community. This cohort study included 7,992 participants who were free of sarcopenia in 2011 in the China Health and Retirement Longitudinal Study and were followed up in 2013 and 2015. Sarcopenia was assessed using the recommendations of the Asian Working Group for Sarcopenia 2019. Longitudinal associations between AIP and sarcopenia and its components were assessed using Cox proportional risk regression modeling. The results showed that AIP was negatively associated with sarcopenia [HR and 95% CI: 0.73 (0.62–0.86)]; with muscle mass [β and 95%CI: 0.49 (0.4–0.57)], skeletal muscle mass index [β and 95%CI: 0.17 (0.15–0.2)], and grip strength [β and 95% CI: 0.17 (0.15–0.2)] being positively correlated. A lower AIP was associated with a lower muscle mass and handgrip strength and higher incidence of sarcopenia. Regular measurement of AIP in the middle-aged and older population in the community can help in the early diagnosis and intervention of sarcopenia.https://doi.org/10.1038/s41598-025-86398-wAtherogenic index of plasmaTriglycerideHigh-density lipoprotein cholesterolSarcopeniaCHARLS |
| spellingShingle | Zhiping Duan Yunda Huang Xiaoling Liu Huiyu Tang Guihua Jiang Wei Huang Runfen Du Dan Zhou Hong Yang A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia Scientific Reports Atherogenic index of plasma Triglyceride High-density lipoprotein cholesterol Sarcopenia CHARLS |
| title | A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| title_full | A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| title_fullStr | A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| title_full_unstemmed | A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| title_short | A lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| title_sort | lower atherogenic index of plasma was associated with a higher incidence of sarcopenia |
| topic | Atherogenic index of plasma Triglyceride High-density lipoprotein cholesterol Sarcopenia CHARLS |
| url | https://doi.org/10.1038/s41598-025-86398-w |
| work_keys_str_mv | AT zhipingduan aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT yundahuang aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT xiaolingliu aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT huiyutang aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT guihuajiang aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT weihuang aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT runfendu aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT danzhou aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT hongyang aloweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT zhipingduan loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT yundahuang loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT xiaolingliu loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT huiyutang loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT guihuajiang loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT weihuang loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT runfendu loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT danzhou loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia AT hongyang loweratherogenicindexofplasmawasassociatedwithahigherincidenceofsarcopenia |