Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration

Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration

Intervertebral disc degeneration (IVDD) is recognized as a significant underlying factor contributing to clinical neck and low back pain. The cartilaginous endplates (CEP) serve as a selectively permeable barrier, which is essential for maintaining the internal homeostasis of the intervertebral disc...

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Main Authors: Jiangminghao Zhao, Peichuan Xu, Tao Li, Jinghong Yuan, Wenrui Zhao, Rui Ding, Guoyu Yang, Jiajun Xie, Guanfeng Huang, Zhidong Peng, Xinxin Miao, Xigao Cheng
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Intervertebral disc degeneration
Lipid nanoparticle
Cartilage targeting
CEBPE
LTF
JAK2/STAT3 inflammatory signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425005976
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