Mono-<i>N</i>-alkylation of Amphotericin B and Nystatin A<sub>1</sub> and Its Amides: Effect on the In Vitro Activity, Cytotoxicity and Permeabilization of Model Membranes

Mono-<i>N</i>-alkylation of Amphotericin B and Nystatin A<sub>1</sub> and Its Amides: Effect on the In Vitro Activity, Cytotoxicity and Permeabilization of Model Membranes

<b>Objectives</b>: In 2022, the World Health Organization highlighted the necessity for the development of new antifungal agents. Polyene antibiotics are characterized by a low risk of drug resistance; however, their use is limited by low solubility and severe side effects. <b>Meth...

Full description

Saved in:
Bibliographic Details
Main Authors: Olga Omelchuk, Elena Bychkova, Svetlana Efimova, Natalia Grammatikova, George Zatonsky, Lyubov Dezhenkova, Svetlana Solovieva, Olga Ostroumova, Anna Tevyashova, Andrey Shchekotikhin
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Antibiotics
Subjects:
amphotericin B
nystatin
polyene antibiotics
antifungal activity
antibiofilm activity
membrane permeabilization
Online Access:https://www.mdpi.com/2079-6382/13/12/1177
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/2079-6382/13/12/1177

Similar Items