Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure

Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure

Abstract Objective Dilated cardiomyopathy (DCM)-associated heart failure (HF) presents a significant clinical challenge, underlying epigenetic mechanisms remaining poorly understood. This study aims to investigate the interplay between DNA methylation and gene expression in the hearts of patients wi...

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Main Authors: Zhenglong Guo, Yunfei Liu, Zhiming Zhou, Jianchao Chen, Lin Guo, Keke Liang, Yibin Hao, Bingtao Hao, Bin Yang, Shixiu Liao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Clinical Epigenetics
Subjects:
DNA methylation
RNA-seq
WGBS
Heart failure
Atrial tissue
Dilated cardiomyopathy
Online Access:https://doi.org/10.1186/s13148-025-01876-2
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https://doi.org/10.1186/s13148-025-01876-2

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