Disentangling effects of the DR and DQ isomers encoded by the HLA class II haplotype DRB1*15:01/DQB1*06:02 to help establish the true risk allele for FVIII inhibitor development in Hemophilia A

Disentangling effects of the DR and DQ isomers encoded by the HLA class II haplotype DRB1*15:01/DQB1*06:02 to help establish the true risk allele for FVIII inhibitor development in Hemophilia A

IntroductionHemophilia A (HA) patients (HAPs) with the human leukocyte antigen (HLA)-class-II (HLAII) haplotype DRB1*15:01/DQB1*06:02, and thus antigen presenting cells which express HLAII β-polypeptide chains that form heterodimers of DR15- and DQ6-serotypes, respectively, have an increased risk of...

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Main Authors: Vincent P. Diego, Bernadette W. Luu, Marcio A. Almeida, Raja Rajalingam, Marco Hofmann, Jacob A. Galan, Eron G. Manusov, Jerry S. Powell, Long V. Dinh, Henry Mead, Huy Huynh, Anne M. Verhagen, Juan M. Peralta, Paul V. Lehmann, Satish Kumar, Eli J. Fine, Joanne E. Curran, Harald H. Goring, Miguel A. Escobar, Sarah Williams-Blangero, Eugene Maraskovsky, John Blangero, Tom E. Howard
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Genetics
Subjects:
Hemophilia A
therapeutic FVIII proteins
FVIII inhibitors
linkage disequilibrium and HLAII haplotype DRB1*15:01/DQB1*06:02
dendritic cell protein processing and presentation assays
therapeutic FVIII derived peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1506862/full
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https://www.frontiersin.org/articles/10.3389/fgene.2025.1506862/full

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