GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation

GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation

Abstract Background Pulmonary fibrosis is a serious interstitial lung disease with no viable treatment except for lung transplantation. Glucagon-like peptide-1 receptor (GLP-1R), commonly regarded as an antidiabetic target, exerts antifibrotic effects on various types of organ fibrosis. However, whe...

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Bibliographic Details
Main Authors: Chenyang Liu, Qun Zhang, Hong Zhou, Linling Jin, Chang Liu, Mingxia Yang, Xinyun Zhao, Wenqiu Ding, Weiping Xie, Hui Kong
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Translational Medicine
Subjects:
Pulmonary fibrosis
GLP-1R
NLRP3 inflammasome
Glycolysis
Histone lactylation
Online Access:https://doi.org/10.1186/s12967-024-05753-z
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https://doi.org/10.1186/s12967-024-05753-z

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