Reduced IFN-γ-expressing SARS-CoV-2 specific CD4+ T cells and transient CD8 + T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals

Reduced IFN-γ-expressing SARS-CoV-2 specific CD4+ T cells and transient CD8 + T cell activation associate with higher HOMA-IR 1-year post COVID-19 in obese individuals

Abstract Insulin resistance is one of the metabolic complications of COVID-19. Our previous study showed a 22% median increase in homeostasis model assessment-estimated insulin resistance (HOMA-IR) in obese individuals at 12 months post-infection compared to acute infection. This study aimed to inve...

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Bibliographic Details
Main Authors: Rona Kartika, Dicky Levenus Tahapary, Farid Kurniawan, Syahidatul Wafa, Tika Pradnjaparamita, Simon P. Jochems, Heri Wibowo, Imam Subekti
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
COVID-19
Insulin resistance
Senescent
Exhaustion
T cells
Online Access:https://doi.org/10.1038/s41598-025-11714-3
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https://doi.org/10.1038/s41598-025-11714-3

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