Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression

Multi-omics analysis reveals the impact of YAP/TEAD4-mediated EIF5A1 expression on mitochondrial apoptosis and bladder cancer progression

Abstract Background Eukaryotic Initiation Factor 5A1 (EIF5A1) is a translation factor, and its pro-tumorigenic role has been extensively documented across various cancer types. However, its specific function in bladder cancer (BLCA) remains unclear. Methods We integrated proteomics and transcriptomi...

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Bibliographic Details
Main Authors: Kun-peng Li, Shun Wan, Chen-yang Wang, Si-yu Chen, Li Wang, Shan-hui Liu, Li Yang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Cancer
Subjects:
Bladder cancer
EIF5A1
YAP/TEAD4
JAK/STAT
Mitochondrial apoptosis
Online Access:https://doi.org/10.1186/s12885-025-13522-4
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https://doi.org/10.1186/s12885-025-13522-4

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