CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/383091 |
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| _version_ | 1832548153610469376 |
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| author | J. Thome A. N. Coogan A. G. Woods C. C. Darie F. Häßler |
| author_facet | J. Thome A. N. Coogan A. G. Woods C. C. Darie F. Häßler |
| author_sort | J. Thome |
| collection | DOAJ |
| description | Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation. |
| format | Article |
| id | doaj-art-cf357ac0c6dc420a9e24ca7bea3c8f52 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-cf357ac0c6dc420a9e24ca7bea3c8f522025-02-03T06:42:14ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/383091383091CLOCK Genes and Circadian Rhythmicity in Alzheimer DiseaseJ. Thome0A. N. Coogan1A. G. Woods2C. C. Darie3F. Häßler4Department of Psychiatry, University of Rostock, Gehlsheimerstraße 20, 18147 Rostock, GermanyDepartment of Psychology, National University of Ireland, Maynooth, Maynooth, IrelandBiochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USABiochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USADepartment of Child and Adolescent Psychiatry and Neurology, University of Rostock, 18147 Rostock, GermanyDisturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.http://dx.doi.org/10.4061/2011/383091 |
| spellingShingle | J. Thome A. N. Coogan A. G. Woods C. C. Darie F. Häßler CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease Journal of Aging Research |
| title | CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease |
| title_full | CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease |
| title_fullStr | CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease |
| title_full_unstemmed | CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease |
| title_short | CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease |
| title_sort | clock genes and circadian rhythmicity in alzheimer disease |
| url | http://dx.doi.org/10.4061/2011/383091 |
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