CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease

Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the...

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Main Authors: J. Thome, A. N. Coogan, A. G. Woods, C. C. Darie, F. Häßler
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:Journal of Aging Research
Online Access:http://dx.doi.org/10.4061/2011/383091
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author J. Thome
A. N. Coogan
A. G. Woods
C. C. Darie
F. Häßler
author_facet J. Thome
A. N. Coogan
A. G. Woods
C. C. Darie
F. Häßler
author_sort J. Thome
collection DOAJ
description Disturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.
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series Journal of Aging Research
spelling doaj-art-cf357ac0c6dc420a9e24ca7bea3c8f522025-02-03T06:42:14ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/383091383091CLOCK Genes and Circadian Rhythmicity in Alzheimer DiseaseJ. Thome0A. N. Coogan1A. G. Woods2C. C. Darie3F. Häßler4Department of Psychiatry, University of Rostock, Gehlsheimerstraße 20, 18147 Rostock, GermanyDepartment of Psychology, National University of Ireland, Maynooth, Maynooth, IrelandBiochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USABiochemistry and Proteomics Group, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, NY 13699, USADepartment of Child and Adolescent Psychiatry and Neurology, University of Rostock, 18147 Rostock, GermanyDisturbed circadian rhythms with sleep problems and disrupted diurnal activity are often seen in patients suffering from Alzheimer disease (AD). Both endogenous CLOCK genes and external Zeitgeber are responsible for the maintenance of circadian rhythmicity in humans. Therefore, modifications of the internal CLOCK system and its interactions with exogenous factors might constitute the neurobiological basis for clinically observed disruptions in rhythmicity, which often have grave consequences for the quality of life of patients and their caregivers. Presently, more and more data are emerging demonstrating how alterations of the CLOCK gene system might contribute to the pathophysiology of AD and other forms of dementia. At the same time, the impact of neuropsychiatric medication on CLOCK gene expression is under investigation.http://dx.doi.org/10.4061/2011/383091
spellingShingle J. Thome
A. N. Coogan
A. G. Woods
C. C. Darie
F. Häßler
CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
Journal of Aging Research
title CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
title_full CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
title_fullStr CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
title_full_unstemmed CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
title_short CLOCK Genes and Circadian Rhythmicity in Alzheimer Disease
title_sort clock genes and circadian rhythmicity in alzheimer disease
url http://dx.doi.org/10.4061/2011/383091
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AT ccdarie clockgenesandcircadianrhythmicityinalzheimerdisease
AT fhaßler clockgenesandcircadianrhythmicityinalzheimerdisease