Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways

Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways

Although enteric glial cell (EGC) abnormal activation is reported to be involved in the pathogenesis of Parkinson's disease (PD), and inhibition of EGC gliosis alleviated gut and dopaminergic neuronal dysfunction was verified in our previous study, the potential role of gut microbiota on EGC fu...

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Bibliographic Details
Main Authors: Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Parkinson's disease
Enteric glia cells
3-Indolepropionic acid
16S rRNA
Pregnane X receptor
IL-13Rα1
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001066
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