CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells

CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells

Introduction: Owing to the limited treatment options for hepatocellular carcinoma (HCC), interventions targeting pre-HCC stages have attracted increasing attention. In the pre-HCC stage, hepatic tumor-initiating cells (hTICs) proliferate abnormally and contribute to hepatocarcinogenesis. Numerous st...

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Main Authors: Miaomiao Chen, Wenjian Chen, Shiwen Sun, Yanli Lu, Guoxiu Wu, Hongyu Xu, Huiru Yang, Chong Li, Weizhi He, Mingyang Xu, Xiuhua Li, Dong Jiang, Yongchao Cai, Changcheng Liu, Wencheng Zhang, Zhiying He
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Journal of Advanced Research
Subjects:
HCC
CDK4/6 inhibitors
Tumor-initiating cells
Cellular senescence
Cyclin D-CDK4/6-INK4-Rb pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2090123224003746
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