Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics
Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/260348 |
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| author | Petra Hudler Nina Kocevar Radovan Komel |
| author_facet | Petra Hudler Nina Kocevar Radovan Komel |
| author_sort | Petra Hudler |
| collection | DOAJ |
| description | Despite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies. |
| format | Article |
| id | doaj-art-ceb85e8d908f4ebc8e2c8a4dc8a7405e |
| institution | DOAJ |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-ceb85e8d908f4ebc8e2c8a4dc8a7405e2025-08-20T03:23:46ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/260348260348Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer DiagnosticsPetra Hudler0Nina Kocevar1Radovan Komel2Medical Centre for Molecular Biology, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaMedical Centre for Molecular Biology, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaMedical Centre for Molecular Biology, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Vrazov trg 2, 1000 Ljubljana, SloveniaDespite remarkable progress in proteomic methods, including improved detection limits and sensitivity, these methods have not yet been established in routine clinical practice. The main limitations, which prevent their integration into clinics, are high cost of equipment, the need for highly trained personnel, and last, but not least, the establishment of reliable and accurate protein biomarkers or panels of protein biomarkers for detection of neoplasms. Furthermore, the complexity and heterogeneity of most solid tumours present obstacles in the discovery of specific protein signatures, which could be used for early detection of cancers, for prediction of disease outcome, and for determining the response to specific therapies. However, cancer proteome, as the end-point of pathological processes that underlie cancer development and progression, could represent an important source for the discovery of new biomarkers and molecular targets for tailored therapies.http://dx.doi.org/10.1155/2014/260348 |
| spellingShingle | Petra Hudler Nina Kocevar Radovan Komel Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics The Scientific World Journal |
| title | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
| title_full | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
| title_fullStr | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
| title_full_unstemmed | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
| title_short | Proteomic Approaches in Biomarker Discovery: New Perspectives in Cancer Diagnostics |
| title_sort | proteomic approaches in biomarker discovery new perspectives in cancer diagnostics |
| url | http://dx.doi.org/10.1155/2014/260348 |
| work_keys_str_mv | AT petrahudler proteomicapproachesinbiomarkerdiscoverynewperspectivesincancerdiagnostics AT ninakocevar proteomicapproachesinbiomarkerdiscoverynewperspectivesincancerdiagnostics AT radovankomel proteomicapproachesinbiomarkerdiscoverynewperspectivesincancerdiagnostics |