Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations.

Titin-Truncating variants predispose to dilated cardiomyopathy in populations genetically similar to african and european reference populations.

The effect of high percentage spliced in (hiPSI) TTN truncating variants (TTNtvs) on risk of dilated cardiomyopathy (DCM) has historically been studied among population subgroups defined by genetic similarity to European reference populations. This has raised questions about the effect of TTNtvs in...

Full description

Saved in:
Bibliographic Details
Main Authors: John DePaolo, Marc R Bornstein, Renae Judy, Sarah Abramowitz, Shefali S Verma, Michael G Levin, Penn Medicine Biobank, Zoltan Arany, Scott M Damrauer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011727
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1371/journal.pgen.1011727

Similar Items