Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7.

Innate killing of Leishmania donovani by macrophages of the splenic marginal zone requires IRF-7.

Highly phagocytic macrophages line the marginal zone (MZ) of the spleen and the lymph node subcapsular sinus. Although these macrophages have been attributed with a variety of functions, including the uptake and clearance of blood and lymph-borne pathogens, little is known about the effector mechani...

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Bibliographic Details
Main Authors: Rebecca Phillips, Mattias Svensson, Naveed Aziz, Asher Maroof, Najmeeyah Brown, Lynette Beattie, Nathalie Signoret, Paul M Kaye
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000813&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1000813&type=printable

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