Histone deacetylase-2 inducer like theophylline has a potential to improve glucocorticoid responsiveness in severe uncontrolled asthma by reducing P-glycoprotein/MRP-1

Histone deacetylase-2 inducer like theophylline has a potential to improve glucocorticoid responsiveness in severe uncontrolled asthma by reducing P-glycoprotein/MRP-1

Background: Epigenetic factors play an essential role in regulating the action of steroids in asthma. Steroids suppress inflammation by recruiting histone deacetylase-2 (HDAC-2), which removes the acetyl group of the nuclear factor kappa B-enabled inflammatory gene complex and disables its action. P...

Full description

Saved in:
Bibliographic Details
Main Authors: Ravi Mishra, Zia Hashim, Mansi Gupta, Rachna Chaturvedi, Harshit Singh, Alok Nath, Durga Prasanna Misra, Ajmal Khan, Mohit Kumar Rai, Shivani Srivastava, Saurabh Chaturvedi, Vikas Agarwal
Format: Article
Language:English
Published: SAGE Publishing 2022-01-01
Series:Indian Journal of Rheumatology
Subjects:
histone deacetylase-2
p-glycoprotein/mrp-1
severe uncontrolled asthma
steroid responsiveness
theophylline
trichostatin a
Online Access:http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=1;spage=47;epage=56;aulast=
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2022;volume=17;issue=1;spage=47;epage=56;aulast=

Similar Items