Virtual screening, molecular dynamics simulations, and in vitro analysis of Sophora flavescens-derived aloperine against Haemonchus contortus

Virtual screening, molecular dynamics simulations, and in vitro analysis of Sophora flavescens-derived aloperine against Haemonchus contortus

IntroductionThe resistance of Haemonchus contortus to ivermectin (IVM) poses a significant economic threat to the global livestock industry. This necessitates alternative strategies for managing the development of drug resistance in H. contortus.MethodsThis study employed molecular docking screening...

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Bibliographic Details
Main Authors: Anben Li, Yan Ma, Wenxi Li, Bintao Zhai, Nana Fu, Jun Li, Qianyu Zhou, Yang Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Veterinary Science
Subjects:
Haemonchus contortus
virtual screening
aloperine
IVM
HC-Pgp
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1620324/full
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https://www.frontiersin.org/articles/10.3389/fvets.2025.1620324/full

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