Elevated plasma GDF15 combined with FGF21 suggests mitochondrial dysfunction in a subgroup of anorexia nervosa patients

Elevated plasma GDF15 combined with FGF21 suggests mitochondrial dysfunction in a subgroup of anorexia nervosa patients

Abstract Growth and differentiation factor 15 (GDF15) is a significant player in cellular stress and energy homeostasis. GDF15 is elevated in cancer cachexia, chemotherapy-induced anorexia, hyperemesis gravidarum, and mitochondrial disorders. Here we analyze GDF15 in anorexia nervosa (AN), a psychia...

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Main Authors: Jingjing Xu, Ruyue Zhang, Vincent Millischer, Miranda Stiernborg, Claire E. Tume, Sara Mehdinia, Peter Barker, Zeynep Yilmaz, Vanessa F. Gonçalves, Catharina Lavebratt, Mikael Landén, Stephen O’Rahilly, Cynthia M. Bulik, Ida AK Nilsson
Format: Article
Language:English
Published: Nature Publishing Group 2025-06-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-025-03425-0
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https://doi.org/10.1038/s41398-025-03425-0

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