Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2

Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-r...

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Bibliographic Details
Main Authors: Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
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Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500049X
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