Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2

Microglia TRPC1 SUMOylation drives neuroinflammation after stroke by modulating NLRP3 activity via increasing TRPC1 interaction with ARRB2

Microglial canonical transient receptor potential channel 1 (TRPC1) has been proposed to influence neuroinflammation after cerebral ischemia and reperfusion injury (CIRI), however, the underlying mechanism remains poorly understood. This study demonstrates that TRPC1 is modified by small ubiquitin-r...

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Bibliographic Details
Main Authors: Huinan Zhang, Xinzhe Du, Tian Gao, Xing Wang, Huifeng Zhang, Manyang Yu, Jing Huang
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
ARRB2
TRPC1
SUMOylation
NLRP3
Stroke
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500049X
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