Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.

Identification of effective subdominant anti-HIV-1 CD8+ T cells within entire post-infection and post-vaccination immune responses.

Defining the components of an HIV immunogen that could induce effective CD8+ T cell responses is critical to vaccine development. We addressed this question by investigating the viral targets of CD8+ T cells that potently inhibit HIV replication in vitro, as this is highly predictive of virus contro...

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Main Authors: Gemma Hancock, Hongbing Yang, Elisabeth Yorke, Emma Wainwright, Victoria Bourne, Alyse Frisbee, Tamika L Payne, Mark Berrong, Guido Ferrari, Denis Chopera, Tomas Hanke, Beatriz Mothe, Christian Brander, M Juliana McElrath, Andrew McMichael, Nilu Goonetilleke, Georgia D Tomaras, Nicole Frahm, Lucy Dorrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-02-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004658&type=printable
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004658&type=printable

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