Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis

Exploring the relationship between graft dysfunction with serum metabolites and inflammatory proteins: integrating Mendelian randomization, single-cell analysis, machine learning, and SHAP methods for comprehensive analysis

Background The exact mechanism of graft dysfunction has not been fully clarified. We aimed to explore the causal effects of serum metabolites on graft dysfunction and the mediating role of inflammatory proteins.Methods We first analyzed the causal association of 1,091 serum metabolites and 91 inflam...

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Bibliographic Details
Main Authors: Jiyuan Li, Kankan Shui, Longkai Peng, Helong Dai, Fenghua Peng
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Renal Failure
Subjects:
N-acetylaspartylgluta­mate
graft dysfunction
IL-2RB
Mendelian randomization
machine learning
SHAP
Online Access:https://www.tandfonline.com/doi/10.1080/0886022X.2025.2516773
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https://www.tandfonline.com/doi/10.1080/0886022X.2025.2516773

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