Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison

Cervical EVT isolation for non-invasive fetal HLA typing in early pregnancy is limited by purity and maternal cell contamination; a methodological comparison

IntroductionMaternal-fetal HLA compatibility influences pregnancy outcome, including preeclampsia risk. Cervical extravillous trophoblasts (EVT) in early pregnancy provide a non-invasive source for fetal genome acquisition, potentially enabling fetal HLA typing for obstetric risk assessment. This st...

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Bibliographic Details
Main Authors: Liseanne J. van ‘t Hof, Johanna M. Kapsenberg, Jos J.M. Drabbels, Lotte E. van der Meeren, Dave L. Roelen, Michael Eikmans, Marie-Louise P. van der Hoorn
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
Trophoblast Retrieval and Isolation from the Cervix (TRIC)
Fluorescence-activated cell sorting (FACS) Prenatal testing
Extravillous Trophoblast
Human Leukocyte Antigen (HLA)
Preeclampsia.
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575086/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1575086/full

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