Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE’s multiethnic population

Pharmacogenomic insights into atorvastatin and rosuvastatin adverse effects: a prospective observational study in the UAE’s multiethnic population

Abstract Background Statins are essential for managing cardiovascular disease (CVD), but adverse effects often lead to treatment discontinuation and non-adherence, underscoring the need for personalized approaches. This study aimed to evaluate the influence of pharmacogenomic (PGx) variants and demo...

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Main Authors: Mais N. Alqasrawi, Zeina N. Al‑Mahayri, Areej S. AlBawa’neh, Lubna Q. Khasawneh, Lilas Dabaghie, Sahar M. Altoum, Dana Hamza, Virendra Misra, Husam Ouda, Salahdein Aburuz, Fatima Al-Maskari, Juma AlKaabi, George P. Patrinos, Bassam R. Ali
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Human Genomics
Subjects:
Cardiovascular disease
Statins
Pharmacogenomics
SLCO1B1
ABCG2
Atorvastatin
Online Access:https://doi.org/10.1186/s40246-025-00753-6
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https://doi.org/10.1186/s40246-025-00753-6

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