Obesity increases DNA damage in the breast epithelium

Obesity increases DNA damage in the breast epithelium

Abstract Obesity is a modifiable risk factor for breast cancer. Yet, how obesity contributes to cancer initiation is not fully understood. The goal of this study was to determine if the body mass index (BMI) and metabolic hallmarks of obesity are related to DNA damage in normal breast tissue. In a m...

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Main Authors: Mohamed Gaber, Arnaud Quentel, Julia Holmes, Cassandra Lepetit, Hana Triki, Adam Wilson, Valerie Payne, Iliana Tenvooren, Cloé Dehours, Abigail Peoples, Mary L. Duet, Adam J. Katz, Thierry Pécot, Gwenola Bougras-Cartron, Pierre-François Cartron, Katherine L. Cook, Pierre-Alexandre Vidi
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer risk
Obesity
Cancer health disparities
Molecular markers
DNA double-strand breaks
3D cell culture
Online Access:https://doi.org/10.1186/s13058-025-01961-7
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https://doi.org/10.1186/s13058-025-01961-7

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