PROTACs improve selectivity for targeted proteins
Proteolysis targeting chimera (PROTAC) technology has emerged as a powerful tool in drug discovery that enables targeted protein degradation through a unique bifunctional approach. This review provides a comprehensive overview of PROTACs with a focus on recent advances in enhancing selectivity and t...
Saved in:
| Main Authors: | Lihua Liu, Xian Guan, Jiezhen Zhuo, Xifeng Wu, Xin Han |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2025-04-01
|
| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2025-0015 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
PROTACs targeting epigenetic proteins
by: Chao Zhang, et al.
Published: (2023-11-01) -
PROTAC-induced protein structural dynamics in targeted protein degradation
by: Kingsley Y Wu, et al.
Published: (2025-02-01) -
Application of PROTACs in target identification and validation
by: Yang Liu, et al.
Published: (2024-02-01) -
PROTAC Delivery Strategies for Overcoming Physicochemical Properties and Physiological Barriers in Targeted Protein Degradation
by: Endry Wahyu Syahputra, et al.
Published: (2025-04-01) -
Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
by: Guliang Yang, et al.
Published: (2022-03-01)