Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay

Molecular detection of hrHPV-induced high-grade squamous intraepithelial lesions of the cervix through a targeted RNA next generation sequencing assay

Abstract Background Cervical cancer screening programs are increasingly relying on sensitive molecular approaches as primary tests to detect high-risk human papillomaviruses (hrHPV), the causative agents of cervix cancer. Although hrHPV infection is a pre-requisite for the development of most precan...

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Main Authors: Julia Faillace Thiesen, Elise Jacquemet, Pascal Campagne, Denis Chatelain, Etienne Brochot, Yves-Edouard Herpe, Nolwenn M. Dheilly, Fabrice Bouilloux, Bénédicte Rognon, Alexandre Douablin, Guillaume Leboucher, Florent Percher, Marc Eloit, Philippe Pérot
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Medicine
Subjects:
Human Papillomavirus (HPV)
Molecular test
Screening
Precancerous lesions
Transcriptome
Next-Generation Sequencing (NGS)
Online Access:https://doi.org/10.1186/s10020-025-01238-x
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https://doi.org/10.1186/s10020-025-01238-x

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