Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection.

Influenza A Virus Challenge Models in Cynomolgus Macaques Using the Authentic Inhaled Aerosol and Intra-Nasal Routes of Infection.

Non-human primates are the animals closest to humans for use in influenza A virus challenge studies, in terms of their phylogenetic relatedness, physiology and immune systems. Previous studies have shown that cynomolgus macaques (Macaca fascicularis) are permissive for infection with H1N1pdm influen...

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Main Authors: Anthony C Marriott, Mike Dennis, Jennifer A Kane, Karen E Gooch, Graham Hatch, Sally Sharpe, Claudia Prevosto, Gail Leeming, Elsa-Gayle Zekeng, Karl J Staples, Graham Hall, Kathryn A Ryan, Simon Bate, Nathifa Moyo, Catherine J Whittaker, Bassam Hallis, Nigel J Silman, Ajit Lalvani, Tom M Wilkinson, Julian A Hiscox, James P Stewart, Miles W Carroll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0157887&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0157887&type=printable

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