Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy

Super-resolution of nodal and paranodal disruption in anti-pan-neurofascin-associated autoimmune nodopathy

IntroductionIn autoimmune nodopathies, autoantibodies target the nodes of Ranvier, impairing saltatory nerve conduction. Understanding the impact of autoantibody binding on protein assembly is crucial for gaining insights into the pathogenicity of different autoantibodies. We investigated nodal, par...

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Main Authors: Vinicius da Cruz Neris Geßner, Janis Theobald Linke, Thomas-Otavio Peulen, Luise Appeltshauser, Claudia Sommer, Dirk Brämer, Christian Geis, Katrin Gertrud Heinze, Kathrin Doppler
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
autoimmune nodopathy
polyneuropathy
dSTORM
Caspr-1
pan-neurofascin
node of Ranvier
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540859/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1540859/full

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