A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

A patient-derived HCC spheroid system to model the tumor microenvironment and treatment response

Background & Aims: Hepatocellular carcinoma (HCC) is the third-leading and fastest rising cause of cancer-related death worldwide. The discovery and preclinical development of compounds targeting HCC are hampered by the absence of authentic tractable systems recapitulating the heterogeneity...

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Main Authors: Emilie Crouchet, Nuno Almeida, Sarah C. Durand, Marie Parnot, Marine A. Oudot, Fabio Giannone, Cloé Gadenne, Natascha Roehlen, Antonio Saviano, Emanuele Felli, Patrick Pessaux, Hong Tuan Duong, Hideki Ohdan, Hiroshi Aikata, Kazuaki Chayama, Thomas F. Baumert, Catherine Schuster
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:JHEP Reports
Subjects:
Liver cancer
3D model
Tumor spheroids
Drug discovery and development
Immuno-oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555924002568
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